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Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

  • Liu, Yan1, 2
  • Chu, John Man Tak1, 2
  • Yan, Tim2
  • Zhang, Yan1, 2
  • Chen, Ying1, 2
  • Chang, Raymond Chuen Chung2, 3
  • Wong, Gordon Tin Chun1
  • 1 The University of Hong Kong, Room K424, Queen Mary Hospital, Pokfulam, Hong Kong, SAR, China , Hong Kong (China)
  • 2 The University of Hong Kong, Hong Kong, SAR, China , Hong Kong (China)
  • 3 The University of Hong Kong, L4-49, Laboratory Block, Pokfulam, Hong Kong, SAR, China , Hong Kong (China)
Published Article
Journal of Neuroinflammation
Springer (Biomed Central Ltd.)
Publication Date
Jan 03, 2020
DOI: 10.1186/s12974-019-1653-7
Springer Nature


BackgroundBoth human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized.MethodsWe evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading.ResultsCompared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated.ConclusionsShort-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer’s disease.

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