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Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension

  • Brash, Lauren
  • Barnes, Gareth D.
  • Brewis, Melanie J.
  • Church, A. Colin
  • Gibbs, Simon J.
  • Howard, Luke S.G.E.
  • Jayasekera, Geeshath
  • Johnson, Martin K.
  • McGlinchey, Neil
  • Onorato, Joelle
  • Simpson, Joanne
  • Stirrat, Colin
  • Thomson, Stephen
  • Watson, Geoffrey
  • Wilkins, Martin R.
  • Xu, Carrie
  • Welsh, David J.
  • Newby, David E.
  • Peacock, Andrew J.
Publication Date
Mar 28, 2018
PubMed Central
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Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr(1))apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr(1))apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170)

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