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Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Authors
  • Milkovic, Lidija1
  • Cipak Gasparovic, Ana1
  • Cindric, Marina2
  • Mouthuy, Pierre-Alexis3
  • Zarkovic, Neven1
  • 1 Laboratory for Oxidative Stress, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia
  • 2 Laboratory for Molecular Pathology, Department of Pathology and Cytology, University Hospital Centre Zagreb, Salata 10, 10000 Zagreb, Croatia
  • 3 ical Research Unit, Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
Type
Published Article
Journal
Cells
Publisher
MDPI AG
Publication Date
Jul 30, 2019
Volume
8
Issue
8
Identifiers
DOI: 10.3390/cells8080793
PMID: 31366062
PMCID: PMC6721558
Source
PubMed Central
Keywords
License
Green

Abstract

The importance of reactive oxygen species (ROS) has been gradually acknowledged over the last four decades. Initially perceived as unwanted products of detrimental oxidative stress, they have been upgraded since, and now ROS are also known to be essential for the regulation of physiological cellular functions through redox signaling. In the majority of cases, metabolic demands, along with other stimuli, are vital for ROS formation and their actions. In this review, we focus on the role of ROS in regulating cell functioning and communication among themselves. The relevance of ROS in therapy concepts is also addressed here.

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