Affordable Access

deepdyve-link
Publisher Website

Short interfering RNA against Bax attenuates TNFα-induced ototoxicity in rat organ of Corti explants.

Authors
  • Dinh, Christine1
  • Bas, Esperanza
  • Dinh, John
  • Vu, Ly
  • Gupta, Chhavi
  • Van De Water, Thomas R
  • 1 University of Miami Ear Institute, Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Type
Published Article
Journal
Otolaryngology
Publisher
SAGE Publications
Publication Date
May 01, 2013
Volume
148
Issue
5
Pages
834–840
Identifiers
DOI: 10.1177/0194599813477631
PMID: 23401256
Source
Medline
License
Unknown

Abstract

TNFα initiates the programmed cell death of auditory HCs in OC explants through upregulation of proapoptotic Bax gene and protein expression. Bax siRNA blocks TNFα-induced apoptosis of HCs by decreasing the TNFα-induced levels of Bax mRNA and protein expression in treated explants. Bax siRNA is an effective treatment for TNFα-induced ototoxicity in OC explants in vitro and has great potential to be a therapeutic agent against trauma/inflammation-induced hearing loss.

Report this publication

Statistics

Seen <100 times