Affordable Access

deepdyve-link
Publisher Website

Short Communication: A Quantitative System for Monitoring Blood-Circulating Viral Protein R of Human Immunodeficiency Virus-1 Detected a Possible Link with Pathogenic Indices.

Authors
  • Matsunaga, Akihiro1
  • Oka, Masako1
  • Iijima, Kenta1
  • Shimura, Mari1
  • Gatanaga, Hiroyuki2
  • Oka, Shinichi2
  • Ishizaka, Yukihito1
  • 1 1 Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. , (Japan)
  • 2 2 AIDS Clinical Center, Hospital, National Center for Global Health and Medicine, Tokyo, Japan. , (Japan)
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Jul 01, 2019
Volume
35
Issue
7
Pages
660–663
Identifiers
DOI: 10.1089/AID.2019.0016
PMID: 30938169
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We developed a detergent-free enzyme-linked immunosorbent assay (ELISA) for HIV-1 viral protein R (Vpr), an accessory protein of human immunodeficiency virus type-1 (HIV), and detected soluble Vpr in ∼22% of HIV patients who were receiving combination antiretroviral therapy and were free of plasma HIV RNA. Notably, the levels of CD8-positive cell count, soluble intercellular adhesion molecule-1 (sICAM-1), and C-C motif chemokine ligand 2 (CCL2), all of which are markers of chronic inflammation in HIV patients, were higher in Vpr-positive patients than in Vpr-negative patients. Because sICAM1 and CCL2 are associated with an increased risk of HIV-associated neurocognitive disorder, we propose that an established Vpr-ELISA would be useful for monitoring the risk of HIV complications during latent HIV infection.

Report this publication

Statistics

Seen <100 times