A sheep model for the study of focal epilepsy with concurrent intracranial EEG and functional MRI.
- Published Article
- Publication Date
Aug 01, 2002
We have developed an animal model of partial epilepsy in which seizures can be reliably elicited with concurrent fMRI and intracranial EEG. During unilateral electrographic seizures, focal BOLD signal changes occurred at the seizure focus and ipsilateral amygdala, suggesting the presence of a cortico-subcortical loop. This observation illustrates the potential of the model for understanding seizure generation, spread, and possibly the consequences of repeated seizures on the brain.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12180994