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A sheep model for the study of focal epilepsy with concurrent intracranial EEG and functional MRI.

Authors
Type
Published Article
Journal
Epilepsia
Publication Date
Volume
43
Issue
8
Pages
779–787
Identifiers
PMID: 12180994
Source
Medline
License
Unknown

Abstract

We have developed an animal model of partial epilepsy in which seizures can be reliably elicited with concurrent fMRI and intracranial EEG. During unilateral electrographic seizures, focal BOLD signal changes occurred at the seizure focus and ipsilateral amygdala, suggesting the presence of a cortico-subcortical loop. This observation illustrates the potential of the model for understanding seizure generation, spread, and possibly the consequences of repeated seizures on the brain.

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