Affordable Access

The sheep as a model for osteoporosis in humans.

Authors
  • Turner, A S
Type
Published Article
Journal
The Veterinary Journal
Publisher
Elsevier
Publication Date
May 01, 2002
Volume
163
Issue
3
Pages
232–239
Identifiers
PMID: 12090765
Source
Medline
License
Unknown

Abstract

There is great interest in large animal models for studying different aspects of osteoporosis. Several laboratories around the world have used ovariectomized sheep as a model because of their ease of housing and handling, low expense compared to other large animals, availability and acceptance in society as a research animal. They have been used to study the response to new therapies for post-menopausal osteoporosis, low-magnitude mechanical stimulation, orthopedic implants in osteoporotic bone and bioactive ceramics to strengthen vertebral bodies. To produce severely osteopenic bone comparable to that seen in humans, a combination of estrogen deficiency following ovariectomy plus a calcium-wasting diet is currently being investigated.

Report this publication

Statistics

Seen <100 times