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A shared HLA-DRB1 epitope in the DR beta first domain is associated with Vogt-Koyanagi-Harada syndrome in Indian patients.

Authors
  • Tiercy, Jean-Marie
  • Rathinam, Sivakumar R
  • Gex-Fabry, Marianne
  • Baglivo, Edoardo
Type
Published Article
Journal
Molecular vision
Publication Date
Jan 01, 2010
Volume
16
Pages
353–358
Identifiers
PMID: 20216938
Source
Medline
License
Unknown

Abstract

Based on the association of HLA-DRB1*0405 and HLA-DRB1*0410 alleles with VKH disease, we propose that the epitope S57-LLEQRRAA (67-74) in the third hypervariable region of the HLA-DRbeta1 molecule is the relevant susceptibility epitope. This genetic component seems specific to VKH disease since no correlation could be identified in SO patients. The weaker association with HLA-DR4 in this VKH patient cohort compared to VKH patients from northern India is probably related to the lower frequency of HLA-DRB1*0405 in our study group. The HLA-DRB1 association with susceptibility to VKH syndrome seems weaker in Indian patients compared to Japanese or Hispanic patients, suggesting a different non-HLA immunogenetic background in Indian VKH patients.

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