Affordable Access

deepdyve-link
Publisher Website

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.

Authors
  • Munn-Chernoff, Melissa A1
  • Johnson, Emma C2
  • Chou, Yi-Ling2
  • Coleman, Jonathan R I3, 4
  • Thornton, Laura M1
  • Walters, Raymond K5, 6
  • Yilmaz, Zeynep1, 7
  • Baker, Jessica H1
  • Hübel, Christopher3, 8
  • Gordon, Scott9
  • Medland, Sarah E9
  • Watson, Hunna J1, 10, 11
  • Gaspar, Héléna A3, 4
  • Bryois, Julien8
  • Hinney, Anke12
  • Leppä, Virpi M8
  • Mattheisen, Manuel13, 14, 15, 16
  • Ripke, Stephan5, 6, 17
  • Yao, Shuyang8
  • Giusti-Rodríguez, Paola7
  • And 332 more
  • 1 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 2 Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • 3 Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • 4 National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Trust, London, UK.
  • 5 Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • 6 Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
  • 7 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 9 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. , (Australia)
  • 10 School of Psychology, Curtin University, Perth, Western Australia, Australia. , (Australia)
  • 11 School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia. , (Australia)
  • 12 Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. , (Germany)
  • 13 Department of Biomedicine, Aarhus University, Aarhus, Denmark. , (Denmark)
  • 14 Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 15 Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden. , (Sweden)
  • 16 Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany. , (Germany)
  • 17 Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany. , (Germany)
  • 18 Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK.
  • 19 Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. , (Netherlands)
  • 20 Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands. , (Netherlands)
  • 21 Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 22 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 23 Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan. , (Japan)
  • 24 Division of Mental Health and Addiction, NORMENT Centre, University of Oslo, Oslo University Hospital, Oslo, Norway. , (Norway)
  • 25 Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  • 26 Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. , (Germany)
  • 27 Centre of Psychiatry and Neuroscience, INSERM U894, Paris, France. , (France)
  • 28 Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
  • 29 Department of Medical Biology, School of Medicine, University of Split, Split, Croatia. , (Croatia)
  • 30 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany. , (Germany)
  • 31 Klinikum Frankfurt/Oder, Frankfurt, Germany. , (Germany)
  • 32 Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Italy. , (Italy)
  • 33 Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. , (Switzerland)
  • 34 Department of Biomedicine, University of Basel, Basel, Switzerland. , (Switzerland)
  • 35 Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Germany. , (Germany)
  • 36 Department of Molecular and Integrative Physiology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • 37 Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France. , (France)
  • 38 Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA.
  • 39 Altrecht Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, The Netherlands. , (Netherlands)
  • 40 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • 41 School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • 42 Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany. , (Germany)
  • 43 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece. , (Greece)
  • 44 Department of Neurosciences, University of Padova, Padova, Italy. , (Italy)
  • 45 College of Nursing, Seattle University, Seattle, Washington, USA.
  • 46 Department of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 47 College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 48 Department of Human & Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 49 Department of Psychiatry, Athens University Medical School, Athens University, Athens, Greece. , (Greece)
  • 50 l'institut du thorax, INSERM, CNRS, Univ Nantes, Nantes, France. , (France)
  • 51 Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 52 Barcelona Institute of Science and Technology, Barcelona, Spain. , (Spain)
  • 53 Universitat Pompeu Fabra, Barcelona, Spain. , (Spain)
  • 54 Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. , (Spain)
  • 55 Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
  • 56 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Würzburg, Würzburg, Germany. , (Germany)
  • 57 Estonian Genome Center, University of Tartu, Tartu, Estonia. , (Estonia)
  • 58 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
  • 59 Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain. , (Spain)
  • 60 Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain. , (Spain)
  • 61 Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain. , (Spain)
  • 62 Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany. , (Germany)
  • 63 Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich, Munich, Germany. , (Germany)
  • 64 Department of Child and Adolescent Psychiatry, University of Münster, Münster, Germany. , (Germany)
  • 65 Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. , (Czechia)
  • 66 Centre for Human Genetics, University of Marburg, Marburg, Germany. , (Germany)
  • 67 Institute of Human Genetics, School of Medicine & University Hospital Bonn, University of Bonn, Bonn, Germany. , (Germany)
  • 68 Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. , (Switzerland)
  • 69 Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 70 Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. , (Germany)
  • 71 1st Psychiatric Department, National and Kapodistrian University of Athens, Medical School, Eginition Hospital, Athens, Greece. , (Greece)
  • 72 Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France. , (France)
  • 73 CMME (GHU Paris Psychiatrie et Neurosciences), Paris Descartes University, Paris, France. , (France)
  • 74 Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • 75 Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  • 76 Helmholtz Zentrum München - German Research Centre for Environmental Health, Institute of Translational Genomics, Neuherberg, Germany. , (Germany)
  • 77 Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 78 Zorg op Orde, Delft, The Netherlands. , (Netherlands)
  • 79 Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany. , (Germany)
  • 80 Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • 81 Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, Massachusetts, USA.
  • 82 Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany. , (Germany)
  • 83 Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan. , (Japan)
  • 84 Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic. , (Czechia)
  • 85 Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain. , (Spain)
  • 86 Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic. , (Czechia)
  • 87 Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. , (Finland)
  • 88 Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. , (Austria)
  • 89 Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands. , (Netherlands)
  • 90 Centre for Addiction and Mental Health, Toronto, Ontario, Canada. , (Canada)
  • 91 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 92 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 93 Department of Public Health, University of Helsinki, Helsinki, Finland. , (Finland)
  • 94 Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
  • 95 Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea. , (North Korea)
  • 96 Department of Psychology, Michigan State University, East Lansing, Michigan, USA.
  • 97 Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway. , (Norway)
  • 98 Department of Clinical Science, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway. , (Norway)
  • 99 Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. , (Norway)
  • 100 Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway. , (Norway)
  • 101 The Chicago School of Professional Psychology, Washington DC Campus, Washington, District of Columbia, USA.
  • 102 Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland. , (Poland)
  • 103 BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. , (Saudi Arabia)
  • 104 Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland. , (Switzerland)
  • 105 Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy. , (Italy)
  • 106 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. , (Switzerland)
  • 107 Department of Paediatric Laboratory Medicine, Division of Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, Canada. , (Canada)
  • 108 NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway. , (Norway)
  • 109 Department of Psychiatry, University College Cork, Cork, Ireland. , (Ireland)
  • 110 Eist Linn Adolescent Unit, Bessborough, Health Service Executive South, Cork, Ireland. , (Ireland)
  • 111 Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. , (Estonia)
  • 112 Molecular Epidemiology Section (Department of Biomedical Datasciences), Leiden University Medical Centre, Leiden, The Netherlands. , (Netherlands)
  • 113 Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland. , (Switzerland)
  • 114 Division of Child and Adolescent Psychiatry, Geneva University Hospital, Geneva, Switzerland. , (Switzerland)
  • 115 National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA.
  • 116 Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA.
  • 117 Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy. , (Italy)
  • 118 Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy. , (Italy)
  • 119 Kartini Clinic, Portland, Oregon, USA.
  • 120 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
  • 121 Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. , (Netherlands)
  • 122 Department of Medicine, Center for Molecular Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. , (Sweden)
  • 123 Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland. , (Finland)
  • 124 Center for Human Genome Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • 125 Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain. , (Spain)
  • 126 Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain. , (Spain)
  • 127 Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain. , (Spain)
  • 128 Institute of Clinical Medicine, University of Oslo, Oslo, Norway. , (Norway)
  • 129 Department of Health Science, University of Florence, Florence, Italy. , (Italy)
  • 130 Department of Biometry, University of Helsinki, Helsinki, Finland. , (Finland)
  • 131 Department of Child and Adolescent Psychiatry, Faculty of Medicine, Eating Disorders Research and Treatment Center, Technische Universität Dresden, Dresden, Germany. , (Germany)
  • 132 Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy. , (Italy)
  • 133 Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 134 Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy. , (Italy)
  • 135 Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany. , (Germany)
  • 136 Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. , (Canada)
  • 137 McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 138 Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • 139 J. Craig Venter Institute (JCVI), La Jolla, California, USA.
  • 140 Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. , (Austria)
  • 141 Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic. , (Czechia)
  • 142 Molecular Epidemiology Section (Department of Medical Statistics), Leiden University Medical Centre, Leiden, The Netherlands. , (Netherlands)
  • 143 Center for Eating Disorders Ursula, Rivierduinen, Leiden, The Netherlands. , (Netherlands)
  • 144 Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands. , (Netherlands)
  • 145 Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. , (Poland)
  • 146 IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. , (Italy)
  • 147 Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland. , (Poland)
  • 148 Department of Psychiatry, University of Naples SUN, Naples, Italy. , (Italy)
  • 149 Department of Psychiatry, University of Perugia, Perugia, Italy. , (Italy)
  • 150 Brain Sciences Department, Stremble Ventures, Limassol, Cyprus. , (Cyprus)
  • 151 Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece. , (Greece)
  • 152 Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece. , (Greece)
  • 153 Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, The Netherlands. , (Netherlands)
  • 154 Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany. , (Germany)
  • 155 BioRealm, LLC, Walnut, California, USA.
  • 156 Oregon Research Institute, Eugene, Oregon, USA.
  • 157 Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 158 The Center for Eating Disorders at Sheppard Pratt, Baltimore, Maryland, USA.
  • 159 Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA.
  • 160 Eating Recovery Center, Denver, Colorado, USA.
  • 161 Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • 162 Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA.
  • 163 Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. , (Australia)
  • 164 Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 165 Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA.
  • 166 David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
  • 167 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 168 Centre for Mental Health, University Health Network, Toronto, Ontario, Canada. , (Canada)
  • 169 Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada. , (Canada)
  • 170 The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark. , (Denmark)
  • 171 Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark. , (Denmark)
  • 172 Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. , (Denmark)
  • 173 Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. , (Australia)
  • 174 National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark. , (Denmark)
  • 175 Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark. , (Denmark)
  • 176 Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 177 Canterbury District Health Board, Christchurch, New Zealand. , (New Zealand)
  • 178 Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. , (New Zealand)
  • 179 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. , (Sweden)
  • 180 Department of Psychiatry, Division of Human Genetics, Yale School of Medicine, New Haven, Connecticut, USA.
  • 181 Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.
  • 182 Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA. , (India)
  • 183 Faculty of Business, Karabuk University, Karabuk, Turkey. , (Turkey)
  • 184 Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 185 Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 186 Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.
  • 187 Psychiatric Genomics and Pharmacogenomics Program, Mayo Clinic, Rochester, Minnesota, USA.
  • 188 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • 189 Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
  • 190 Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • 191 Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
  • 192 Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • 193 Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany. , (Germany)
  • 194 Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA.
  • 195 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. , (Germany)
  • 196 Laboratory of Neurogenetics, NIH/NIAAA, Bethesda, Maryland, USA.
  • 197 Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland. , (Switzerland)
  • 198 Institute of Medical Genetics and Pathology, University Hospital Basel, University Hospital Basel, Basel, Switzerland. , (Switzerland)
  • 199 Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. , (Netherlands)
  • 200 Turku Institute for Advanced Studies, University of Turku, Turku, Finland. , (Finland)
  • 201 Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. , (Finland)
  • 202 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA. , (India)
  • 203 Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • 204 Division of Psychiatry, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • 205 Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
  • 206 Department of Psychiatry and Behavioral Sciences, Henri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, New York, USA.
  • 207 Department of Psychiatry, Amsterdam Public Health Research Institute, VU University Medical Center/GGz inGeest, Amsterdam, The Netherlands. , (Netherlands)
  • 208 Department of Sociology, Harvard University, Cambridge, Massachusetts, USA.
  • 209 Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.
  • 210 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts, USA.
  • 211 Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • 212 Institute of Behavioral Science, University of Colorado, Boulder, Colorado, USA.
  • 213 Department of Sociology, University of Colorado, Boulder, Colorado, USA.
  • 214 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
  • 215 Department of Psychiatry, University of Vermont Medical Center, Burlington, Vermont, USA.
  • 216 Department of Medicine, Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri, USA.
  • 217 Department of Psychiatry, University of Mainz, Mainz, Germany. , (Germany)
  • 218 National Drug and Alcohol Research Centre, University of New South Wales, Sydney, New South Wales, Australia. , (Australia)
  • 219 Stanford University Graduate School of Education, Stanford University, Stanford, California, USA.
  • 220 Department of Psychiatry and Psychotherapy, University of Düsseldorf, Duesseldorf, Germany. , (Germany)
  • 221 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • 222 Max-Planck-Institute of Psychiatry, Munich, Germany. , (Germany)
  • 223 Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
  • 224 Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. , (Germany)
  • 225 Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. , (Germany)
  • 226 Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
  • 227 Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • 228 Department of Psychiatry, University of Bonn, Bonn, Germany. , (Germany)
  • 229 Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. , (Finland)
  • 230 Department of Statistical Genetics, Max-Planck-Institute of Psychiatry, München, Germany. , (Germany)
  • 231 Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK.
  • 232 Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA. , (India)
  • 233 Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Herborn, Germany. , (Germany)
  • 234 Department of Psychiatry and Psychotherapy, Vitos Hospital Herborn, Herborn, Germany. , (Germany)
  • 235 School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • 236 Department of Psychiatry and Psychotherapy, University of Regensburg Psychiatric Health Care Aargau, Regensburg, Germany. , (Germany)
  • 237 Department of Psychiatry and Psychotherapy and Department of Addictive Behaviour and Addiction Medicine, Medical Faculty, LVR-Hospital Essen, University of Duisburg-Essen, Essen, Germany. , (Germany)
  • 238 Medical Park Chiemseeblick in Bernau-Felden, Ludwig-Maximilians-University, Bernau am Chiemsee, Germany. , (Germany)
  • 239 Psychiatric Hospital, Ludwig-Maximilians-University, Bernau am Chiemsee, Germany. , (Germany)
  • 240 Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany. , (Germany)
  • 241 Department of Psychiatry, Psychiatric Hospital, Ludwig-Maximilians-University, Munich, Germany. , (Germany)
  • 242 Department of Sociology, University of Utah, Salt Lake City, Utah, USA.
  • 243 Department of Psychology, University of California San Diego, San Diego, California, USA.
  • 244 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA.
  • 245 Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois, USA.
  • 246 NIAAA Intramural Research Program, Bethesda, Maryland, USA.
  • 247 Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland. , (Finland)
  • 248 National Institute for Health and Welfare, Helsinki, Finland. , (Finland)
  • 249 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • 250 Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.
  • 251 Department of Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA.
  • 252 Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA.
  • 253 Office of the Clinical Director, NIH/NIAAA, Besthesda, Maryland, USA.
  • 254 Center for Omics Discovery and Epidemiology, Behavioral Health Research Division, RTI International, Research Triangle Park, North Carolina, USA.
  • 255 Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 256 Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • 257 Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
  • 258 Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.
  • 259 Department of Psychiatry, University of Colorado Denver, Aurora, Colorado, USA.
  • 260 Fellow Program, RTI International, Research Triangle Park, North Carolina, USA.
  • 261 Center for Studies of Addiction, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  • 262 VISN 4 MIRECC, Crescenz VAMC, Philadelphia, Pennsylvania, USA.
  • 263 Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, Colorado, USA.
  • 264 Peter Boris Centre for Addictions Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. , (Canada)
  • 265 Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University/St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. , (Canada)
  • 266 Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
  • 267 Department of Psychiatry, Amsterdam UMC, VU University and GGZinGeest, Amsterdam, The Netherlands. , (Netherlands)
  • 268 Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, Indiana, USA. , (India)
  • 269 Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, Connecticut, USA.
  • 270 School of Psychology, Flinders University, Adelaide, South Australia, Australia. , (Australia)
  • 271 Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. , (Australia)
  • 272 Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.
  • 273 Department of Neuroscience, Yale School of Medicine, New Haven, Connecticut, USA.
  • 274 Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Type
Published Article
Journal
Addiction Biology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Feb 16, 2020
Identifiers
DOI: 10.1111/adb.12880
PMID: 32064741
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. © 2020 Society for the Study of Addiction.

Report this publication

Statistics

Seen <100 times