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A shared epitope found in the major paralysis inducing tick species of Africa.

Authors
  • Crause, J C
  • van Wyngaardt, S
  • Gothe, R
  • Neitz, A W
Type
Published Article
Journal
Experimental & applied acarology
Publication Date
Jan 01, 1994
Volume
18
Issue
1
Pages
51–59
Identifiers
PMID: 7543039
Source
Medline
License
Unknown

Abstract

Cross-reactivity between all the paralysis inducing tick species of veterinary relevance in Africa was demonstrated, by using a monoclonal antibody directed against the paralysis inducing toxin of Rhipicephalus evertsi evertsi. Western blot results, together with amino acid composition studies indicated that this monoclonal antibody recognizes protein bands of similar molecular mass and amino acid composition in R. evertsi evertsi and Ixodes rubicundus. This suggests that the Karoo paralysis toxin of I. rubicundus is possibly also a trimer with a high degree of homology to the spring lamb paralysis toxin of R. evertsi evertsi. The conclusive identity of these protein bands of I. rubicundus could not be shown. Bio-assay studies performed on 1-day-old chickens suggested that the anti-spring lamb paralysis toxin monoclonal antibody also recognizes the paralysis toxin present in Argas (Persicargas) walkerae, by rendering some degree of protection against the effect of this toxin.

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