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SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization

Authors
  • Antas, Pedro1
  • Novellasdemunt, Laura1
  • Kucharska, Anna1
  • Massie, Isobel1
  • Carvalho, Joana1
  • Oukrif, Dahmane2
  • Nye, Emma1
  • Novelli, Marco2
  • Li, Vivian S.W.1
  • 1 The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK
  • 2 Histopathology Department, University College London Hospitals NHS Foundation Trust, London, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Feb 26, 2019
Volume
26
Issue
9
Pages
2266–2273
Identifiers
DOI: 10.1016/j.celrep.2019.01.110
PMID: 30811977
PMCID: PMC6391711
Source
PubMed Central
Keywords
License
Unknown

Abstract

Antas et al. find that SH3BP4 is transcriptionally activated by Wnt in the intestinal crypt to inhibit Wnt activity as a negative feedback mechanism. SH3BP4 restricts β-catenin nuclear localization at the perinuclear region. Deletion of Sh3bp4 increases stem cell numbers and accelerates intestinal tumor development in mice.

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