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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications.

Authors
  • Singh, Shalini1
  • Ahmed, Doaa1, 2
  • Dolatshad, Hamid1
  • Tatwavedi, Dharamveer1
  • Schulze, Ulrike3
  • Sanchi, Andrea1
  • Ryley, Sarah4
  • Dhir, Ashish5
  • Carpenter, Lee6
  • Watt, Suzanne M6
  • Roberts, David J7
  • Abdel-Aal, Amal M2
  • Sayed, Sohair K2
  • Mohamed, Somaia A2
  • Schuh, Anna8
  • Vyas, Paresh9, 10
  • Killick, Sally11
  • Kotini, Andriana G12, 13, 14, 15
  • Papapetrou, Eirini P12, 13, 14, 15
  • Wiseman, Daniel H16
  • And 2 more
  • 1 Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • 2 Clinical Pathology Department, Assiut University, Assiut, Egypt. , (Egypt)
  • 3 Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • 4 Oxford Medical Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, The Churchill Hospital, Oxford, UK.
  • 5 Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • 6 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • 7 National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK.
  • 8 Molecular Diagnostic Centre, Department of Oncology, University of Oxford, Oxford, UK.
  • 9 MRC Molecular Hematology Unit, WIMM, University of Oxford, Oxford, UK.
  • 10 Haematology Theme Oxford Biomedical Research Centre and Department of Hematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • 11 Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK.
  • 12 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 13 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 14 Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 15 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 16 Division of Cancer Sciences, University of Manchester, Manchester, UK.
  • 17 Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. [email protected]
  • 18 Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. [email protected]
Type
Published Article
Journal
Leukemia
Publisher
Springer Nature
Publication Date
Sep 01, 2020
Volume
34
Issue
9
Pages
2525–2530
Identifiers
DOI: 10.1038/s41375-020-0753-9
PMID: 32076118
Source
Medline
Language
English
License
Unknown
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