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Severe Generalized Weakness, Paralysis, and Aphasia following Administration of Irinotecan and Oxaliplatin during FOLFIRINOX Chemotherapy.

Authors
  • Chandar, Manisha1
  • de Wilton Marsh, Robert2
  • 1 University of Chicago (North Shore), North Shore University Health System, Evanston, Ill., USA.
  • 2 Kellogg Cancer Center, North Shore University Health System, Evanston, Ill., USA.
Type
Published Article
Journal
Case reports in oncology
Publication Date
Jan 01, 2015
Volume
8
Issue
1
Pages
138–141
Identifiers
DOI: 10.1159/000380849
PMID: 25873880
Source
Medline
Keywords
License
Unknown

Abstract

In selected cases, coadministration of irinotecan and oxaliplatin may result in severe generalized weakness and aphasia, which may be triggered by underlying electrolyte disturbances. Careful monitoring and correction of potassium may help prevent this reaction.

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