Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection.

Kashef Ijaz; John A Jereb; Lauren A Lambert; William A Bower; Philip R Spradling; Peter D McElroy; Michael F Iademarco; Thomas R Navin; Kenneth G Castro

Severe or fatal liver injury in 50 patients in the United States taking rifampin and pyrazinamide for latent tuberculosis infection.

Authors

Ijaz, Kashef
Jereb, John A
Lambert, Lauren A
Bower, William A
Spradling, Philip R
McElroy, Peter D
Iademarco, Michael F
Navin, Thomas R
Castro, Kenneth G

Type

Published Article

Journal

Clinical Infectious Diseases

Publisher

Oxford University Press

Publication Date

Feb 01, 2006

Volume

42

Issue

3

Pages

346–355

Identifiers

PMID: 16392079

Source

Medline

License

Unknown

Abstract

RZ was the likeliest cause of most of these liver injuries, some of which were fatal in spite of monitoring. Fatality was predicted by age or use of other medications, but none of the cofactors showed promise as a reliable clinical predictor of severe liver injury.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/03/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16392079

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