Affordable Access

Access to the full text

Severe Acute Respiratory Syndrome Coronavirus 2 and Blood Safety: An Updated Review

Authors
  • Kiely, Philip
  • Hoad, Veronica C.
  • Seed, Clive R.
  • Gosbell, Iain B.
Type
Published Article
Journal
Transfusion Medicine and Hemotherapy
Publisher
S. Karger AG
Publication Date
Mar 23, 2022
Volume
49
Issue
4
Pages
218–229
Identifiers
DOI: 10.1159/000522264
PMID: 35528142
PMCID: PMC9059091
Source
Karger
Keywords
Disciplines
  • Review Article
License
Green
External links

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus first identified in late 2019 and subsequently declared a worldwide pandemic in March 2020. In this review, we provide an overview of the implications of SARS-CoV-2 for blood safety and sufficiency. Summary: Approximately one-third of SARS-CoV-2 infections are asymptomatic. The reported mean incubation period typically varies from 2 to 11 days, but longer periods up to 22 days have been reported. The blood phase of SARS-CoV-2 appears to be brief and low level, with RNAaemia detectable in only a small proportion of patients, typically associated with more severe disease and not demonstrated to be infectious virus. A small number of presymptomatic and asymptomatic blood phase cases have been reported. Transfusion-transmission (TT) of SARS-CoV-2 has not been reported. Therefore, the TT risk associated with SARS-CoV-2 is currently theoretical. To mitigate any potential TT risk, but more importantly to prevent respiratory transmission in donor centers, blood services can implement donor deferral policies based on travel, disease status, or potential risk of exposure and encourage staff vaccination. Key Messages: The TT risk of SARS-CoV-2 appears to be low. The biggest risk to blood services in the current COVID-19 pandemic is to maintain the sufficiency of the blood supply while minimizing respiratory transmission of SARS-CoV-2 to donors and staff while donating blood.

Report this publication

Statistics

Seen <100 times