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Several down, a few to go: histamine H3 receptor ligands making the final push towards the market?

Authors
  • Kuhne, Sebastiaan
  • Wijtmans, Maikel
  • Lim, Herman D
  • Leurs, Rob
  • de Esch, Iwan J P
Type
Published Article
Journal
Expert Opinion on Investigational Drugs
Publisher
Informa UK (Taylor & Francis)
Publication Date
December 2011
Volume
20
Issue
12
Pages
1629–1648
Identifiers
DOI: 10.1517/13543784.2011.625010
PMID: 21992603
Source
Medline
License
Unknown

Abstract

A challenging feature in H(3)R research is the multifaceted role of the receptor at a molecular/biochemical level, which can complicate targeting by small molecules at several (pre)clinical levels. Accordingly, H(3)R antagonists/inverse agonists require further testing to pinpoint the determinants for clinical efficacy and to aid in the final push towards the market.

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