Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen.
Allergy Consortium Wageningen, Wageningen University, Wageningen, The Netherlands. [email protected]
- Published Article
Springer (Biomed Central Ltd.)
- Publication Date
Jul 04, 2006
Isoforms of the major birch allergen Bet v 1 are encoded by multiple genes, and we propose to name them accordingly. The present characterization of the Bet v 1 genes provides a framework for the screening of specific Bet v 1 genes among other B. pendula cultivars or Betula species, and for future breeding for trees with a reduced allergenicity. Investigations towards sensitization and immunotherapy should anticipate that patients are exposed to a mixture of Bet v 1 isoforms of different IgE-reactivity, even if pollen originates from a single birch tree.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16820045