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Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen.

Authors
  • 1
  • 1 Allergy Consortium Wageningen, Wageningen University, Wageningen, The Netherlands. [email protected] , (Netherlands)
Type
Published Article
Journal
BMC Genomics
1471-2164
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Pages
168–168
Identifiers
PMID: 16820045
Source
Medline
License
Unknown

Abstract

Isoforms of the major birch allergen Bet v 1 are encoded by multiple genes, and we propose to name them accordingly. The present characterization of the Bet v 1 genes provides a framework for the screening of specific Bet v 1 genes among other B. pendula cultivars or Betula species, and for future breeding for trees with a reduced allergenicity. Investigations towards sensitization and immunotherapy should anticipate that patients are exposed to a mixture of Bet v 1 isoforms of different IgE-reactivity, even if pollen originates from a single birch tree.

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