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Setting apart the affected: the use of behavioral criteria in animal models of post traumatic stress disorder.

Authors
  • Cohen, Hagit
  • Zohar, Joseph
  • Matar, Michael A
  • Zeev, Kaplan
  • Loewenthal, Uri
  • Richter-Levin, Gal
Type
Published Article
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Publication Date
Nov 01, 2004
Volume
29
Issue
11
Pages
1962–1970
Identifiers
PMID: 15257304
Source
Medline
License
Unknown

Abstract

Post-traumatic stress disorder (PTSD) affects about 20-30% of exposed individuals. Clinical studies of PTSD generally employ stringent criteria for inclusion in study populations, and yet in animal studies the data collection and analysis are generally expressed as a function of exposed vs nonexposed populations, regardless of individual variation in response. Prior data support an approach to animal models analogous to inclusion criteria in clinical studies. This series of studies sought to assess prevalence rates of maladaptive vs adaptive responses determined according to a more stringent approach to the concept of inclusion/exclusion criteria (cutoff behavioral criteria-CBC), consisting of two successive behavioral tests (elevated plus maze and acoustic startle response tests). The rats were exposed to stressors in two different paradigms; exposure to a predator and underwater trauma. The prevalence rates of maladaptive responses to stress in these two distinct models dropped over time from 90% in the acute phase to 25% enduring/maladaptive response at 7 days, to remain constant over 30 days. As setting the affected individuals apart from the unaffected approximates clinical studies, it might also help to clarify some of the pending issues in PTSD research.

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