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Serum tumour necrosis factor compared with C-reactive protein in the early assessment of severity of acute pancreatitis.

Authors
  • Paajanen, H
  • Laato, M
  • Jaakkola, M
  • Pulkki, K
  • Niinikoski, J
  • Nordback, I
Type
Published Article
Journal
The British journal of surgery
Publication Date
Feb 01, 1995
Volume
82
Issue
2
Pages
271–273
Identifiers
PMID: 7749709
Source
Medline
License
Unknown

Abstract

Tumour necrosis factor (TNF) is an early mediator of sepsis and multiple organ failure; increased concentrations in serum are also observed in acute pancreatitis. In the present study the predictive value of TNF and C-reactive protein (CRP) concentrations on admission were compared in order to differentiate complicated cases of acute pancreatitis from the mild course in 77 patients. Serum TNF concentration exceeded the detectable level only in seven of 77 patients (9 per cent), although complicated pancreatitis developed in 18 (23 per cent). The sensitivity and overall accuracy of TNF concentration in predicting severe disease were only 16 and 74 per cent respectively. The corresponding values for CRP (concentrations greater than 100 mg/l) were 84 and 74 per cent respectively. These data suggest that, in contrast with CRP, the early determination of peripheral blood TNF concentration is of no clinical value in assessing the severity of acute pancreatitis.

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