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Serum tryptase and the laboratory diagnosis of systemic mastocytosis.

Authors
  • Schwartz, L B
  • Irani, A M
Type
Published Article
Journal
Hematology/Oncology Clinics of North America
Publisher
Elsevier
Publication Date
Jun 01, 2000
Volume
14
Issue
3
Pages
641–657
Identifiers
PMID: 10909044
Source
Medline
License
Unknown

Abstract

Total tryptase levels of 20 ng/mL or higher in a baseline serum sample when the ratio of total to beta-tryptase is 20 or greater strongly suggest underlying systemic mastocytosis. Whether these criteria prove to be more sensitive than a bone marrow biopsy will require further study. Although the absolute level of total tryptase does not predict disease severity, it may provide a practical method for assessing the efficacy of therapeutic interventions designed to reduce the mast cell burden.

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