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Serum transfer of collagen-induced arthritis. II. Identification and localization of autoantibody to type II collagen in donor and recipient rats.

Authors
Type
Published Article
Journal
Arthritis & Rheumatism
Publisher
Wiley (John Wiley & Sons)
Volume
26
Issue
10
Pages
1237–1244
Source
UCSC Bioinformatics biomedical-ucsc
License
Unknown

Abstract

Collagen-induced arthritis can be transferred from immunized arthritic rats to unimmunized recipients by intravenous injection of an immunoglobulin concentrate of sera. This study identifies antibodies in the transfer concentrate which localize to the articular surface of cartilage in joints of recipients. Immunoglobulin can also be demonstrated in the same location in arthritic joints from rats after immunization. Antibody capable of transferring arthritis is present in donor rats over a period of at least 3 weeks and can be absorbed using homologous type II collagen. In addition, anti-type II collagen antibodies can be eluted from arthritic joints of rats with early disease.

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