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Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome.

Authors
  • Disanto, Giulio1
  • Adiutori, Rocco2
  • Dobson, Ruth2
  • Martinelli, Vittorio3
  • Dalla Costa, Gloria3
  • Runia, Tessel4
  • Evdoshenko, Evgeniy5
  • Thouvenot, Eric6
  • Trojano, Maria7
  • Norgren, Niklas8
  • Teunissen, Charlotte9
  • Kappos, Ludwig10
  • Giovannoni, Gavin2
  • Kuhle, Jens11
  • 1 Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK Neurocentre of Southern Switzerland, Ospedale Civico, Lugano, Switzerland. , (Switzerland)
  • 2 Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.
  • 3 Department of Neurology and INSPE, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy. , (Italy)
  • 4 Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 5 Centre of Multiple Sclerosis, City Clinical Hospital 31, St. Petersburg, Russia.
  • 6 Institut de Génomique Fonctionnelle, CNRS UMR5203, INSERM U661, Université Montpellier 1, Université Montpellier 2, Montpellier, France, and Université Montpellier and Hôpital Carémeau, Nîmes, France. , (France)
  • 7 Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Bari, Italy. , (Italy)
  • 8 Uman Diagnostics, Umeå, Sweden. , (Sweden)
  • 9 Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, MS Center, Neurocampus Amsterdam, VU University Medical Centre Amsterdam, The Netherlands. , (Netherlands)
  • 10 Department of Neurology, University Hospital Basel, Basel, Switzerland. , (Switzerland)
  • 11 Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK Department of Neurology, University Hospital Basel, Basel, Switzerland. , (Switzerland)
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Feb 01, 2016
Volume
87
Issue
2
Pages
126–129
Identifiers
DOI: 10.1136/jnnp-2014-309690
PMID: 25716934
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p = 1.5 × 10(-5) and OR = 7.03; 95% CI 2.85 to 17.34; p = 2.3 × 10(-5), respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR = 2.36; 95% CI 1.21 to 4.59; p = 0.011), gadolinium-enhancing lesions (OR = 2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR = 2.54; 95% CI 1.21 to 5.31; p = 0.013) at CIS diagnosis. If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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