Affordable Access

deepdyve-link
Publisher Website

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

Authors
  • Schultz, Stephanie A.1
  • Strain, Jeremy F.1
  • Adedokun, Adedamola1
  • Wang, Qing1
  • Preische, Oliver2, 3
  • Kuhle, Jens4
  • Flores, Shaney1
  • Keefe, Sarah1
  • Dincer, Aylin1
  • Ances, Beau M.1
  • Berman, Sarah B.5
  • Brickman, Adam M.6
  • Cash, David M.7
  • Chhatwal, Jasmeer8
  • Cruchaga, Carlos1
  • Ewers, Michael9
  • Fox, Nick N.10
  • Ghetti, Bernardino11
  • Goate, Alison12
  • Graff-Radford, Neill R.13, 14
  • And 27 more
  • 1 & Immunology, Department of Psychiatry, Division of Biostatistics, Washington University in St. Louis School of Medicine, Saint Louis, MO, USA
  • 2 DZNE-German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany
  • 3 Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany
  • 4 Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland
  • 5 Alzheimer Disease Research Center and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, 4-West Montefiore University Hospital, 200 Lothrop Street, Pittsburgh, PA, USA
  • 6 Department of Neurology, Columbia University Medical Center, New York, NY, USA
  • 7 Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK
  • 8 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • 9 Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany
  • 10 Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK
  • 11 Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
  • 12 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • 13 Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
  • 14 Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
  • 15 Department of Radiology, Mayo Clinic, Rochester, MN, USA
  • 16 Department of Radiology, University of Michigan, Ann Arbor, USA
  • 17 Department of Psychiatry and Human Behavior, Butler Hospital, Warren Alpert Medical School, Brown University, Providence, RI, USA
  • 18 German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
  • 19 Department of Neurology, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany
  • 20 Munich Cluster for Systems Neurology (SyNergy), Germany
  • 21 The Florey Institute, University of Melbourne, Parkville, VIC, Australia
  • 22 Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia
  • 23 Department of Neurology, Butler Hospital, Warren Alpert Medical School, Brown University, Providence, RI, USA
  • 24 Department of Neurology, Department of Radiology, Indiana University School of Medicine, Indianapolis, IN, USA
  • 25 Banner Alzheimer's Institute, Phoenix, AZ, USA
  • 26 Departments of Psychiatry, Radiology, Medicine, and Neurology, University of California at San Francisco, San Francisco, CA, USA
Type
Published Article
Journal
Neurobiology of Disease
Publisher
Elsevier
Publication Date
Aug 01, 2020
Volume
142
Identifiers
DOI: 10.1016/j.nbd.2020.104960
PMID: 32522711
PMCID: PMC7363568
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Serum NfL levels reflect white matter integrity in autosomal dominant Alzheimer disease. • Associations between NfL and white matter imaging are present throughout all brain regions. • Longitudinal white matter alterations are associated with changes in blood NfL. • Results improve interpretability of NfL as a marker of brain integrity.

Report this publication

Statistics

Seen <100 times