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Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment.

Authors
  • Vinayavekhin, Nawaporn1
  • Sueajai, Jetjamnong2
  • Chaihad, Nichaboon3
  • Panrak, Ratchanee4
  • Chokchaisiri, Ratchanaporn5
  • Sangvanich, Polkit6
  • Suksamrarn, Apichart7
  • Piyachaturawat, Pawinee8
  • 1 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand; Omics Sciences and Bioinformatics Center, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: [email protected]
  • 2 Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. Electronic address: [email protected]
  • 3 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: [email protected]
  • 4 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: [email protected]
  • 5 Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. Electronic address: [email protected]
  • 6 Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: [email protected]
  • 7 Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. Electronic address: [email protected]
  • 8 Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand; Chakri Naruebodindra Medical Institute, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Electronic address: [email protected]
Type
Published Article
Journal
Journal of ethnopharmacology
Publication Date
Nov 04, 2016
Volume
192
Pages
273–282
Identifiers
DOI: 10.1016/j.jep.2016.07.054
PMID: 27448454
Source
Medline
Keywords
License
Unknown

Abstract

The findings suggest the potential beneficial effects of C. comosa on preventing the increased ceramide levels in OVX rats, a possible cause of metabolic disturbance under estrogen deficiency. Overall, the results demonstrated the power of untargeted lipidomics in discovering disease-relevant biomarkers, as well as evaluating the effectiveness of treatment by C. comosa components (DPHD, extract or powder) as utilized in Thai traditional medicine, and also providing scientific support for its folklore use.

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