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Serum lipid profile in diabetic macular edema.

Authors
  • Ozer, Pinar Altiaylik1
  • Unlu, Nurten
  • Demir, Muhammed Necati
  • Hazirolan, Dicle Oncel
  • Acar, Mehmet Akif
  • Duman, Sunay
  • 1 Ophthalmology Department, Ankara Education and Research Hospital, Ankara, Turkey. [email protected] , (Turkey)
Type
Published Article
Journal
Journal of diabetes and its complications
Publication Date
Jan 01, 2009
Volume
23
Issue
4
Pages
244–248
Identifiers
DOI: 10.1016/j.jdiacomp.2007.12.004
PMID: 18413202
Source
Medline
Language
English
License
Unknown

Abstract

To evaluate the correlation of lipid profile and clinical presentation of macular edema in Type 2 diabetes mellitus (DM) patients. The study included 20 patients with chronic diabetic macular edema and plaque-like hard exudates (Group 1), 20 patients with diabetic macular edema (Group 2), and 20 DM patients but without retinopathy (Group 3). Diabetic retinopathy was classified according to the Early Treatment Diabetic Retinopathy Study grading system. Sample t test was used to evaluate the association between the fasting serum lipid [total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], glycosylated hemoglobin (HbA1c), fasting blood glucose, creatinine levels, and the clinical findings. P values <.05 were considered statistically significant. There was no difference between fasting serum lipids and HbA1c levels. Duration of diabetes was shorter in Group 3 than in Groups 1 and 2. Patients in Group 1 had longer duration of diabetes than others (P<.05). Creatinine levels in Group 1 were higher than in other groups (P<.05). Although there was no correlation between fasting blood glucose and HbA1c levels, HbA1c was higher in all three groups from the baseline-normal limits (P<.05). No correlation was found between serum lipid levels and macular edema severity, but the duration of diabetes was demonstrated as a significant factor in the progression of macular edema. High HbA1c levels in all patients highlight the importance of intense glycemic control in diabetic patients.

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