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Serum lipid, lipoprotein and apolipoprotein profiles in workers exposed to low arsenic levels: Lipid profiles and occupational arsenic exposure.

Authors
  • Ledda, Caterina1
  • Iavicoli, Ivo2
  • Bracci, Massimo3
  • Avola, Roberto4
  • Senia, Paola5
  • Santarelli, Lory3
  • Pomara, Cristoforo6
  • Rapisarda, Venerando5
  • 1 Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. Electronic address: [email protected] , (Italy)
  • 2 Occupational Medicine, Department of Public Health, University of Naples Federico II, Naples, Italy. , (Italy)
  • 3 Occupational Medicine, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy. , (Italy)
  • 4 Biochemistry, Department of Biomedical Sciences and Biotechnology, University of Catania, Catania, Italy. , (Italy)
  • 5 Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. , (Italy)
  • 6 Megal Medicine, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; Department of Anatomy, University of Malta, Msida, Malta. , (Italy)
Type
Published Article
Journal
Toxicology letters
Publication Date
Jan 05, 2018
Volume
282
Pages
49–56
Identifiers
DOI: 10.1016/j.toxlet.2017.10.014
PMID: 29054558
Source
Medline
Keywords
License
Unknown

Abstract

Epidemiologic studies have reported that exposure to arsenic (As) is associated with higher risk of cardiovascular disease (i.e., coronary heart disease and peripheral arterial heart disease) and mortality. This cross-sectional study aimed to compare serum lipid, lipoprotein, and apolipoprotein profiles in workers exposed to As. The subjects of this study included 57 workers exposed to As and 57 controls. Demographic characteristics and occupational information were collected through questionnaires. Exposure to As was assessed in indoor air of a workplace and determined using the creatinine values in the urine. Blood samples were collected using immunochemistry and nephelometry to measure the levels of total cholesterol (CHOL), triglycerides (TRIG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)), apolipoprotein-A1 (Apo-A1), and apolipoprotein-B (Apo-B). No significant difference in the demographic data was detected between the two groups. Urinary As concentration was significantly (p<0.001) higher in exposed subjects than in the controls (13.4±6.1 and 4.4±6.1μg/gCreat, respectively). No statistically significant differences were observed in CHOL, TRIG, HDL, and LDL concentrations between the two groups. Lp(a), Apo-B, and Apo-B/Apo-A1 ratio values were significantly higher and the Apo-A1 level was significantly lower in the exposed group than in the control subjects. Regression analysis highlighted a significant (p<0.001) association between urinary As and Lp(a), Apo-A1, and Apo-B concentration, and Apo-B/Apo-A1 ratio. This study revealed the influence of As on apolipoproteins, suggesting a potential risk of cardiovascular diseases in subjects exposed to low levels of As.

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