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Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial

Authors
  • Hartl, Agnes1
  • Sieper, Joachim1
  • Syrbe, Uta1
  • Listing, Joachim2
  • Hermann, Kay-Geert3
  • Rudwaleit, Martin4
  • Poddubnyy, Denis1, 2
  • 1 Charité Universitätsmedizin Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Hindenburgdamm 30, Berlin, 12203, Germany , Berlin (Germany)
  • 2 German Rheumatism Research Centre, Charitéplatz 1, Berlin, 10117, Germany , Berlin (Germany)
  • 3 Charité Universitätsmedizin Berlin, Department of Radiology, Charitéplatz 1, Berlin, 10117, Germany , Berlin (Germany)
  • 4 Klinikum Bielefeld Rosenhöhe, An der Rosenhöhe 27, Bielefeld, 33647, Germany , Bielefeld (Germany)
Type
Published Article
Journal
Arthritis Research & Therapy
Publisher
Springer Science and Business Media LLC
Publication Date
Jun 15, 2017
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s13075-017-1350-9
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundPrevious research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the role of adipokine serum levels as predictors of radiographic spinal progression in patients with AS.MethodsA total of 120 patients with definite AS who completed a 2-year follow up in the ENRADAS trial were included in the current study. Radiographic spinal progression was defined as: (1) worsening of the modified Stoke Ankylosing Spondylitis spine (mSASSS) score by ≥2 points and/or (2) new syndesmophyte formation or progression of existing syndesmophytes after 2 years. Serum levels of adipokines (adiponectin (APN) and its high molecular weight form (HMW-APN), chemerin, leptin, lipocalin-2, omentin, resistin, visfatin) were measured using enzyme-linked immunosorbent assays.ResultsThere was a significant association between radiographic spinal progression and both leptin and HMW-APN. Baseline serum levels of both adipokines were lower in patients who showed radiographic spinal progression after 2 years. This association was especially evident in men; they had generally lower leptin and HMW-APN serum levels as compared to women. The inverse association between adipokines and radiographic spinal progression was confirmed in the logistic regression analysis: the odds ratios (OR) for the outcome “no mSASSS progression ≥2 points” were 1.16 (95% CI 1.03 to 1.29) and 1.17 (95% CI 0.99 to 1.38), for leptin and HMW-APN, respectively; for “no syndesmophyte formation/progression” the respective OR were 1.29 (95% CI 1.11 to 1.50) and 1.18 (95% CI 0.98 to 1.42), adjusted for the presence of syndesmophytes at baseline, C-reactive protein at baseline, sex, body mass index (BMI), non-steroidal anti-inflammatory drugs intake score over 2 years, and smoking status at baseline.ConclusionSerum leptin and HMW-APN predict protection from spinal radiographic progression in patients with AS. Women generally have higher leptin and HMW-APN serum levels that might explain why they have less structural damage in the spine as compared to male patients with AS.Trial registrationEudraCT: 2007-007637-39. ClinicalTrials.gov, NCT00715091. Registered on 14 July 2008.

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