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Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on 18 F-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma.

Authors
  • Senjo, Hajime1, 2
  • Kanaya, Minoru1
  • Izumiyama, Koh1
  • Minauchi, Koichiro2
  • Hirata, Kenji3
  • Mori, Akio1
  • Saito, Makoto1
  • Tanaka, Masanori1
  • Iijima, Hiroaki4
  • Tsukamoto, Eriko5
  • Itoh, Kazuo6
  • Ota, Shuichi2
  • Morioka, Masanobu1
  • Hashimoto, Daigo7
  • Teshima, Takanori7
  • 1 Department of Hematology, Aiiku Hospital, Sapporo, Japan. , (Japan)
  • 2 Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan. , (Japan)
  • 3 Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. , (Japan)
  • 4 Clinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, Japan. , (Japan)
  • 5 Department of Radiology, Central CI Clinic, Sapporo, Japan. , (Japan)
  • 6 Department of Radiology, Keiyukai Sapporo Hospital, Sapporo, Japan. , (Japan)
  • 7 Department of Hematology, Faculty of Medicine, Hokkaido University, Sapporo, Japan. , (Japan)
Type
Published Article
Journal
Cancer Medicine
Publisher
Wiley
Publication Date
Mar 01, 2019
Volume
8
Issue
3
Pages
953–962
Identifiers
DOI: 10.1002/cam4.1973
PMID: 30790452
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma. High total metabolic tumor volume (TMTV) calculated using 18 F-FDG PET/CT images at diagnosis predicts poor prognosis of patients with DLBCL. However, high cost and poor access to the imaging facilities hamper wider use of 18 F-FDG PET/CT. In order to explore a surrogate marker for TMTV, we evaluated the correlation between the serum levels of soluble interleukin-2 receptor (sIL-2R) and TMTV in 64 patients with DLBCL, and the results were verified in an independent validation cohort of 86 patients. Serum levels of sIL-2R were significantly correlated with TMTV. ROC analysis revealed that the cutoff value of TMTV ≥150 cm3 or sIL-2R ≥ 1300 U/mL could predict failure to achieve EFS24 with areas under the curve (AUC) 0.706 and 0.758, respectively. Each of TMTV ≥150 cm3 and sIL-2R ≥1300 U/mL was significantly associated with worse 5-year overall survival and event-free survival. Importantly, each of sIL-2R <1300 U/mL or TMTV <150 cm3 identified patients with favorable prognosis among NCCN-IPI high-intermediate and high-risk group. Serum level of sIL-2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by 18 F-FDG PET/CT that can predict treatment outcomes of patients with DLBCL. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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