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Serum inhibits tight junction formation in cultured pigment epithelial cells.

Authors
  • Chang, C W
  • Ye, L
  • Defoe, D M
  • Caldwell, R B
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
May 01, 1997
Volume
38
Issue
6
Pages
1082–1093
Identifiers
PMID: 9152228
Source
Medline
License
Unknown

Abstract

Tight junction formation by RPE cells is inhibited by serum. This activity may play an important role in responses of the RPE layer to injury, contributing to the pathologic progression of blood-retinal barrier dysfunction.

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