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Serum immunoglobulin A concentration in infancy, but not human milk immunoglobulin A, is associated with subsequent atopic manifestations in children and adolescents: a 20-year prospective follow-up study.

Authors
  • Pesonen, M
  • Kallio, M J T
  • Siimes, M A
  • Savilahti, E
  • Ranki, A
Type
Published Article
Journal
Clinical & Experimental Allergy
Publisher
Wiley (Blackwell Publishing)
Publication Date
May 01, 2011
Volume
41
Issue
5
Pages
688–696
Identifiers
DOI: 10.1111/j.1365-2222.2011.03707.x
PMID: 21418342
Source
Medline
License
Unknown

Abstract

Increased serum IgA concentration at age 2 months is associated with the development of subsequent allergic symptoms and sensitization in childhood and adolescence. Maternal milk IgA concentrations are not associated with subsequent allergic symptoms in the recipient infant. The present study provides novel information on the role of IgA in the development of respiratory allergy and sensitization.

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