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Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype.

Authors
  • Barbaro, G
  • Di Lorenzo, G
  • Ribersani, M
  • Soldini, M
  • Giancaspro, G
  • Bellomo, G
  • Belloni, G
  • Grisorio, B
  • Barbarini, G
Type
Published Article
Journal
Journal of Hepatology
Publisher
Elsevier
Publication Date
May 01, 1999
Volume
30
Issue
5
Pages
774–782
Identifiers
PMID: 10365801
Source
Medline
License
Unknown

Abstract

The levels of serum ferritin correlate significantly to lipoperoxidation markers in chronic hepatitis C patients. The increased production of free radicals with a reduced peripheral blood mononuclear cell cytotoxic activity may represent, especially in patients with genotype 1b, a factor underlying the resistance to interferon therapy and may influence the evolution of the liver disease by enhancement of the cytopathic effect of hepatitis C virus.

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