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Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis

Authors
  • Jiang, Qingtao
  • Zhang, Feng
  • Han, Lei
  • Zhu, Baoli
  • Liu, Xin
Type
Published Article
Journal
Gynecologic and Obstetric Investigation
Publisher
S. Karger AG
Publication Date
Jun 14, 2021
Volume
86
Issue
3
Pages
239–246
Identifiers
DOI: 10.1159/000516518
PMID: 34126621
Source
Karger
Keywords
Disciplines
  • Meta-Analysis
License
Green
External links

Abstract

Introduction: The association of serum copper with polycystic ovarian syndrome (PCOS) has been studied for years, but no definite conclusion is drawn. Therefore, we conducted a meta-analysis to investigate serum copper concentrations in PCOS subjects compared with healthy controls. Methods: Electronic search was performed in PubMed, Google Scholar, and Scopus up to June 30, 2020, without any restriction. Standardized mean differences (SMDs) with corresponding 95% CIs in serum copper levels were employed with random-effects model. I<sup>2</sup> was applied to evaluate heterogeneity among studies. Results: Nine studies, measuring plasma copper levels in 1,168 PCOS patients and 1,106 controls, were included. Pooled effect size suggested serum copper level was significantly higher in women with PCOS (SMD = 0.51 μg/mL, 95% CI = [0.30, 0.72], p < 0.0001). The overall heterogeneity was not connected with subgroups of the country, but derived from the opposite result of 1 study. Conclusion: Our research generally indicated circulating copper level in PCOS sufferers was significantly higher than normal controls. Large-scale studies are still needed to elucidate the clear relation between copper status and etiology of PCOS.

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