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Serum Bilirubin and Disease Progression in Mild COPD.

Authors
  • Apperley, Scott1
  • Park, Hye Yun2
  • Holmes, Daniel T3
  • Man, S F Paul4
  • Tashkin, Donald5
  • Wise, Robert A6
  • Connett, John E7
  • Sin, Don D8
  • 1 Department of Medicine, Pulmonary Division, University of British Columbia, Vancouver, BC, Canada.
  • 2 UBC James Hogg Research Centre and the Institute for Heart and Lung Health, St. Paul's Hospital, Vancouver, BC, Canada; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Seoul, South Korea.
  • 3 Department of Pathology, University of British Columbia, Vancouver, BC, Canada.
  • 4 Department of Medicine, Pulmonary Division, University of British Columbia, Vancouver, BC, Canada; UBC James Hogg Research Centre and the Institute for Heart and Lung Health, St. Paul's Hospital, Vancouver, BC, Canada.
  • 5 Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
  • 6 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • 7 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
  • 8 Department of Medicine, Pulmonary Division, University of British Columbia, Vancouver, BC, Canada; UBC James Hogg Research Centre and the Institute for Heart and Lung Health, St. Paul's Hospital, Vancouver, BC, Canada. Electronic address: [email protected]
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
July 2015
Volume
148
Issue
1
Pages
169–175
Identifiers
DOI: 10.1378/chest.14-2150
PMID: 25539285
Source
Medline
License
Unknown

Abstract

Bilirubin is inversely related to COPD disease severity and progression. Higher serum bilirubin concentration was associated with a higher FEV₁ and less annual decline in FEV₁. Bilirubin was also associated with less coronary heart disease mortality. These data support the hypothesis that bilirubin has a protective effect on COPD disease progression, possibly through its antioxidant actions. Bilirubin may prove useful as an easily accessible and readily available blood-based COPD biomarker.

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