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Serum Bilirubin and Disease Progression in Mild COPD.

Authors
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Type
Published Article
Journal
Chest
1931-3543
Publication Date
Volume
148
Issue
1
Pages
169–175
Identifiers
DOI: 10.1378/chest.14-2150
PMID: 25539285
Source
Medline

Abstract

Bilirubin is inversely related to COPD disease severity and progression. Higher serum bilirubin concentration was associated with a higher FEV₁ and less annual decline in FEV₁. Bilirubin was also associated with less coronary heart disease mortality. These data support the hypothesis that bilirubin has a protective effect on COPD disease progression, possibly through its antioxidant actions. Bilirubin may prove useful as an easily accessible and readily available blood-based COPD biomarker.

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