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Serum apelin and resistin levels in patients with impaired fasting glucose, impaired glucose tolerance, type 2 diabetes, and metabolic syndrome.

Authors
  • Onalan, Erhan1
  • Yakar, Burkay2
  • Barım, Abdullah Onder3
  • Gursu, Mehmet Ferit3
  • 1 Department of Internal Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. [email protected] , (Turkey)
  • 2 Deparment of Family Medicine, Faculty of Medicine, Firat University, Elazig, Turkey. , (Turkey)
  • 3 Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey. , (Turkey)
Type
Published Article
Journal
Endokrynologia Polska
Publication Date
Jan 01, 2020
Volume
71
Issue
4
Pages
319–324
Identifiers
DOI: 10.5603/EP.a2020.0024
PMID: 32716043
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to investigate serum apelin and resistin levels in patients with impaired fasting glucose, impaired glucose tolerance, type 2 diabetes and metabolic syndrome. The study comprised 18 patients with type 2 diabetes mellitus (T2DM) (nine females, nine males), 18 patients with impaired fasting glucose (IFG) (nine females, nine males), 18 patients with impaired glucose tolerance (IGT) (nine females, nine males), 18 patients with metabolic syndrome (MeS) (nine females, nine males), and 16 healthy individuals (eight females, eight males); serum adiponectin, apelin, resistin levels, fasting and postprandial blood glucose, insulin resistance markers, and lipid parameters were measured. In the study, serum apelin levels were determined to be significantly lower in IGT, MeS, and T2DM groups compared with the control group (p = 0.002, p = 0.006, and p < 0.001, respectively). Serum resistin levels were determined to be significantly higher in IGT and T2DM groups compared with the control group (p < 0.001 and p < 0.001, respectively). Apelin and resistin are thought to affect glucose metabolism and insulin resistance. Apelin is an important indicator in individuals with IGT in the prediabetic period and may play a role in preventing diabetic complications and treatment of T2DM.

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