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Serum albumin level and long-term outcome in acute heart failure.

Authors
  • Ancion, Arnaud1
  • Allepaerts, Sophie2
  • Robinet, Sébastien1
  • Oury, Cecile1
  • Pierard, Luc A1
  • Lancellotti, Patrizio1, 3
  • 1 University Hospital of Liège, GIGA Cardiovascular Sciences, Acute Care Unit, Heart Failure Clinic, CHU Sart Tilman, Liège, Belgium. , (Belgium)
  • 2 University Hospital of Liège, Geriatric Medicine, CHU Sart Tilman, Liège, Belgium. , (Belgium)
  • 3 Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy. , (Italy)
Type
Published Article
Journal
Acta cardiologica
Publication Date
Dec 01, 2019
Volume
74
Issue
6
Pages
465–471
Identifiers
DOI: 10.1080/00015385.2018.1521557
PMID: 30650026
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objective: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of long-term mortality in patients admitted for acute HF.Methods and results: We examined the association between albumin and hospital mortality in a cohort of 509 patients admitted for acute HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation or presented with acute coronary syndrome or primary valvular disease. Sixty-nine patients (14%) died during the 1-year follow-up. With multivariable analysis, haemoglobin level (p = .003), systolic blood pressure (p = .004) and serum albumin level (p = .003) emerged as independent predictors of long-term mortality. Hypoalbuminemia (<35.7 g/L) had a hazard ratio of 2.01 (95% CI 1.24-3.25) and haemoglobin of 2.6 (95% CI 1.29-5.22) for predicting long-term mortality.Conclusions: Serum albumin level measured at admission, especially if combined with anaemia, can serve as a simple prognostic factor in acute HF for predicting long-term outcome.

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