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Sertraline: a review of its use in the management of major depressive disorder in elderly patients.

Authors
  • Muijsers, Richard B R
  • Plosker, Greg L
  • Noble, Stuart
Type
Published Article
Journal
Drugs & aging
Publication Date
Jan 01, 2002
Volume
19
Issue
5
Pages
377–392
Identifiers
PMID: 12093324
Source
Medline
License
Unknown

Abstract

Sertraline is an effective and well tolerated antidepressant for the treatment of major depressive disorder in patients aged > or =60 years. Since elderly patients are particularly prone to the anticholinergic effects of TCAs as a class, SSRIs such as sertraline are likely to be a better choice for the treatment of major depressive disorder in this age group. In addition, sertraline may have advantages over the SSRIs paroxetine, fluoxetine and fluvoxamine in elderly patients because of the drug's comparatively low potential for drug interactions, which is of importance in patient groups such as the elderly who are likely to receive more than one drug regimen.

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