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Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.

Authors
  • Sinopoli, Vanessa M1, 2
  • Erdman, Lauren2, 3
  • Burton, Christie L2, 4
  • Park, Laura S1, 2
  • Dupuis, Annie5, 6
  • Shan, Janet4
  • Goodale, Tara4
  • Shaheen, S-M7
  • Crosbie, Jennifer4, 8
  • Schachar, Russell J1, 4, 8
  • Arnold, Paul D2, 7, 9
  • 1 Institute of Medical Science, University of Toronto, Toronto, ON, Canada. , (Canada)
  • 2 Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada. , (Canada)
  • 3 Department of Computer Science, University of Toronto, Toronto, ON, Canada. , (Canada)
  • 4 Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada. , (Canada)
  • 5 Clinical Research Services, The Hospital for Sick Children, Toronto, ON, Canada. , (Canada)
  • 6 Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. , (Canada)
  • 7 Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. , (Canada)
  • 8 Department of Psychiatry, University of Toronto, Toronto, ON, Canada. , (Canada)
  • 9 Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. , (Canada)
Type
Published Article
Journal
Depression and anxiety
Publication Date
Aug 01, 2020
Volume
37
Issue
8
Pages
760–770
Identifiers
DOI: 10.1002/da.22996
PMID: 32092211
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hoarding, originally only considered a symptom of obsessive-compulsive disorder (OCD), is now categorized as a separate disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). We studied candidate serotonergic genes and the distinctness of hoarding in children and adolescents and hypothesized that unique gene variants would be associated with hoarding alone. We examined obsessive-compulsive (OC) traits, including hoarding, in a total of 5,213 pediatric participants in the community. We genotyped candidate serotonin genes (5-HTTLPR polymorphism in SLC6A4 for 2,018 individuals and single nucleotide polymorphisms [SNPs] across genes SLC6A4, HTR2A, and HTR1B for 4,711 individuals). In a previous study conducted by our group in the same sample, we identified a significant association between 5-HTTLPR and hoarding in males. In this study, we examined hoarding more closely by testing the association between serotonin gene variants and hoarding traits with and without other accompanying OC traits. The [LG +S] variant in 5-HTTLPR was significantly associated with hoarding alone in males (p-value of 0.009). There were no significant findings for 5-HTTLPR in females. There were no significant findings after correction for multiple comparisons using SNP array data, but top SNP findings suggested that variation downstream of HTR1B may be implicated in hoarding alone in females. Our results suggest specific serotonin gene variants are associated with hoarding traits alone, differing between sexes. Top findings are in line with our former study, suggesting that individuals with hoarding alone were driving previous results. Our paper supports hoarding disorder's new designation. © 2020 Wiley Periodicals, Inc.

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