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Serotonin syndrome caused by olanzapine and clomipramine.

Authors
  • 1
  • 1 Anaesthesiology and Intensive Care Unit, S. Giovanni di Dio Hospital, Crotone, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Minerva anestesiologica
1827-1596
Publication Date
Volume
74
Issue
1-2
Pages
41–45
Identifiers
PMID: 18004234
Source
Medline
License
Unknown

Abstract

We describe a case of severe serotonin syndrome. The patient was simultaneously taking the atypical antidepressant olanzapine and a tricyclical antidepressant, clomipramine. Symptoms included altered mental state resulting in coma, myoclonus, hyperreflexia, diaphoresis, diarrhoea, disorientation and fever. After suspension of antidepressant drugs, intensive symptomatic treatment and administration of biperiden and cyproheptadine, the patient's condition improved.

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