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Serotonin receptor affinity of cathinone and related analogues.

Authors
  • Glennon, R A
  • Liebowitz, S M
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Apr 01, 1982
Volume
25
Issue
4
Pages
393–397
Identifiers
PMID: 7069716
Source
Medline
License
Unknown

Abstract

A series of cathinone (alpha-aminopropiophenone) analogues was examined using the isolated rat fundus preparation. (S)-(-)-Cathinone possesses twice the serotonin receptor affinity of (+/-)-cathinone and four times the affinity of racemic amphetamine. Several derivatives of cathinone were found to either possess a lower affinity than the parent compound or did not interact with the receptors in a competitive manner. Several novel analogues, 1-(aminomethyl)-3,4-dihydronaphthalene hydrochloride (3), 4-(aminomethyl)-3-chromene hydrochloride (4b), as well as its 6-methoxy derivative, a, interact with serotonin receptors but in a fashion which is, most likely, dissimilar to the interaction of the substituted cathinone analogues.

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