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Seroprevalence of SARS-CoV-2 antibodies in the poorest region of Brazil: results from a population-based study.

Authors
  • de Souza Araújo, Adriano Antunes1, 2, 3
  • Quintans-Júnior, Lucindo José2, 3, 4
  • Heimfarth, Luana2
  • Schimieguel, Dulce Marta1, 3
  • Corrêa, Cristiane Bani2, 5
  • de Moura, Tatiana Rodrigues2, 5
  • Cavalcante, Rafael Ciro Marques6
  • Rodrigues Bomfim, Rangel6
  • Grespan, Renata4, 7
  • Santana Rodrigues, Lorranny2
  • Dos Santos, Danillo Menezes2
  • de Sá Resende, Ayane2
  • de Lima Silva, Nathanielly3
  • da Silva Santos, Anna Clara Ramos3
  • Dantas Araújo, Jéssica Maria7
  • de Souza, Mércia Feitosa8
  • de Oliveira Góes, Marco Aurélio8, 9
  • Santana Santos, Victor2, 10
  • Martins-Filho, Paulo Ricardo2, 11
  • 1 Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. , (Brazil)
  • 2 Health Sciences Graduate Program, Federal University of Sergipe, Aracaju, Sergipe, Brazil. , (Brazil)
  • 3 Graduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. , (Brazil)
  • 4 Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. , (Brazil)
  • 5 Department of Morphology, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. , (Brazil)
  • 6 Department of Pharmacy, Federal University of Sergipe, Lagarto, Sergipe, Brazil. , (Brazil)
  • 7 Graduate Program in Physiological Sciences, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil. , (Brazil)
  • 8 Government of Sergipe State, State Health Secretariat, Aracaju, Sergipe, Brazil. , (Brazil)
  • 9 Department of Medicine, Federal University of Sergipe, Lagarto, Sergipe, Brazil. , (Brazil)
  • 10 Centre for Epidemiology and Public Health, Federal University of Alagoas, Arapiraca, Brazil. , (Brazil)
  • 11 Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Sergipe, Brazil. , (Brazil)
Type
Published Article
Journal
Epidemiology and Infection
Publisher
Cambridge University Press
Publication Date
May 18, 2021
Volume
149
Identifiers
DOI: 10.1017/S0950268821001163
PMID: 34001292
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Population-based seroprevalence studies on coronavirus disease 2019 (COVID-19) in low- and middle-income countries are lacking. We investigated the seroprevalence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) antibodies in Sergipe state, Northeast Brazil, using rapid IgM-IgG antibody test and fluorescence immunoassay. The seroprevalence was 9.3% (95% CI 8.5-10.1), 10.2% (95% CI 9.2-11.3) for women and 7.9% (IC 95% 6.8-9.1) for men (P = 0.004). We found a decline in the prevalence of SARS-CoV-2 antibodies according to age, but the differences were not statistically significant: 0-19 years (9.9%; 95% CI 7.8-12.5), 20-59 years (9.3%; 95% CI 8.4-10.3) and ≥60 years (9.0%; 95% CI 7.5-10.8) (P = 0.517). The metropolitan area had a higher seroprevalence (11.7%, 95% CI 10.3-13.2) than outside municipalities (8.0%, 95% CI 7.2-8.9) (P < 0.001). These findings highlight the importance of serosurveillance to estimate the real impact of the COVID-19 outbreak and thereby provide data to better understand the spread of the virus, as well as providing information to guide stay-at-home measures and other policies. In addition, these results may be useful as basic data to follow the progress of COVID-19 outbreak as social restriction initiatives start to be relaxed in Brazil.

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