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Seroprevalence, clinical, and pathological characteristics of canine leishmaniasis in a central region of Colombia

Authors
  • Picón, Yenny1, 2
  • Almario, Geiner1
  • Rodríguez, Victoria1
  • Garcia, Noel Verjan1
  • 1 Immunobiology and Pathogenesis Research Group, Faculty of Veterinary Medicine, University of Tolima, Altos de Santa Helena , (Colombia)
  • 2 Master course in Public Health, Autonomous University of Manizales, Colombia , (Colombia)
Type
Published Article
Journal
Journal of Veterinary Research
Publisher
Sciendo
Publication Date
Feb 14, 2020
Volume
64
Issue
1
Pages
85–94
Identifiers
DOI: 10.2478/jvetres-2020-0011
Source
De Gruyter
Keywords
License
Green

Abstract

Introduction Leishmaniasis is a zoonotic disease which is caused by protozoan parasites of the genus Leishmania. Canids are the most important reservoir of the parasites; however, limited data are available on the species of Leishmania prevalent in these animals and their impact on human health. The objective of this study was to estimate the seroprevalence of leishmaniasis in dogs from an inter-Andean region of Colombia during July 2016–July 2017, and to describe the clinical and histopathological features of the disease. Material and Methods A total of 155 dogs were subjected to clinical examination and a serological test for detection of antibodies against Leishmania. Necropsy was carried out on positive animals and tissue samples were processed by routine histopathology. Results Altogether 19 dogs were positive in the serological test, establishing a 12% seroprevalence of Leishmania. Clinical examination and necropsy revealed exfoliative and ulcerative dermatitis with haemorrhagic borders on the ears, head, nose, and legs. Histopathology revealed severe multifocal dermatitis with abundant Leishmania amastigotes within the cytoplasm of phagocytic cells, depletion of lymphocytes in lymphoid tissues, interstitial pneumonia, and interstitial nephritis. Tissue samples were positive for Leishmania by PCR. Conclusion The macro- and microscopic changes correlated with the presence of Leishmania as established by serological test and PCR.

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