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Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium).

Authors
  • Van der Wielen, Marie
  • Van Damme, Pierre
  • Van Herck, Koen
  • Schlegel-Haueter, Susanna
  • Siegrist, Claire-Anne
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Jun 02, 2003
Volume
21
Issue
19-20
Pages
2412–2417
Identifiers
PMID: 12744872
Source
Medline
License
Unknown

Abstract

To determine age-dependent pertussis immune response in the Flemish population, antibody levels to pertactin (PRN), pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in serum samples from 1622 healthy 1-100-year-old subjects. For anti-PRN and anti-PT antibodies, peaks in GMTs were seen in infancy and again in the 10-15-year age group. After age of 20 years, anti-PRN GMT declined rapidly over a decade, followed by a slower decline. Anti-FHA GMT tended to rather increase progressively with age. These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults.

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