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Seroprevalence of anti-SARS-CoV-2 total antibody is higher in younger Austrian blood donors

Authors
  • Weidner, Lisa1
  • Nunhofer, Verena2
  • Jungbauer, Christof1
  • Hoeggerl, Alexandra Domnica2
  • Grüner, Lydia2
  • Grabmer, Christoph2
  • Zimmermann, Georg3, 4
  • Rohde, Eva2, 5
  • Laner-Plamberger, Sandra2, 5
  • 1 Lower Austria and Burgenland,
  • 2 University Hospital of Salzburg (SALK), Paracelsus Medical University (PMU) Salzburg,
  • 3 Team Biostatistics and Big Medical Data, IDA Lab Salzburg, PMU Salzburg, Strubergasse 16, 5020 Salzburg, Austria
  • 4 Department of Research and Innovation, PMU Salzburg, Strubergasse 16, 5020 Salzburg, Austria
  • 5 Spinal Cord Injury and Tissue Regeneration Centre Salzburg, PMU Salzburg, Strubergasse 21, 5020 Salzburg, Austria
Type
Published Article
Journal
Infection
Publisher
Springer-Verlag
Publication Date
Jun 16, 2021
Pages
1–8
Identifiers
DOI: 10.1007/s15010-021-01639-0
PMCID: PMC8208066
Source
PubMed Central
Keywords
Disciplines
  • Original Paper
License
Unknown

Abstract

Purpose Frequently the infection with coronavirus 2 (SARS-CoV-2) can be asymptomatic or provoke only mild symptoms. These cases often remain unnoticed, so it is difficult to estimate the actual numbers of infections. Aim of this study was to determine the seroprevalence of anti-SARS-CoV-2 total antibody in Austrian blood donors. Methods 20,228 blood donors aged between 18 and 72 years resident in four Austrian federal states were screened for anti-SARS-CoV-2 total antibody between 5th of June and 4th of December 2020. To evaluate the impact of sex, age, AB0-blood group and donation period on the anti-SARS-CoV-2 seroprevalence, multiple logistic regression was done. Results Our data reveal an anti-SARS-CoV-2 seroprevalence of 2.5% overall, significantly depending on the time point of blood donation: after the first Austrian lockdown the seroprevalence was lower compared to the following months, when the rate was constantly rising. While younger blood donors showed significantly higher seroprevalence, no differences were found concerning sex or AB0 blood group. Conclusion Broad testing strategies are required to better determine the number of SARS-CoV-2 infections. Screening blood donors as a representative group for the adult population could be a valid tool to determine the number of recorded and unrecorded cases of SARS-CoV-2 infection.

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