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Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil

Authors
  • Amorim, Luiz Filho1
  • Szwarcwald, Célia Landmann2
  • Mateos, Sheila de Oliveira Garcia1, 3
  • de Leon, Antonio Carlos Monteiro Ponce4
  • Medronho, Roberto de Andrade5
  • Veloso, Valdiléa Gonçalves6
  • Lopes, Josiane Iole França3
  • Porto, Luis Cristovão de Moraes Sobrino7
  • Chieppe, Alexandre8
  • Werneck, Guilherme Loureiro9
  • 1 Hemorio. Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 2 Fundação Instituto Oswaldo Cruz . Instituto de Comunicação e Informação Científica e Tecnológica em Saúde . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 3 Universidade de São Paulo . Faculdade de Medicina da Universidade de São Paulo . São Paulo , SP , Brasil, São Paulo SP , (Brazil)
  • 4 Universidade do Estado do Rio de Janeiro . Instituto de Medicina Social . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 5 Universidade do Federal do Rio de Janeiro . Faculdade de Medicina . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 6 Fundação Instituto Oswaldo Cruz . Instituto Nacional de Infectologia Evandro Chagas . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 7 Universidade do Estado do Rio de Janeiro . Laboratório de Histocompatibilidade e Criopreservação, Policlínica Piquet Carneiro . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 8 Secretaria de Estado do Rio de Janeiro . Rio de Janeiro , RJ , Brasil, Rio de Janeiro RJ , (Brazil)
  • 9 Universidade do Federal do Rio de Janeiro . Instituto de Estudos em Saúde Coletiva . Rio de Janeiro , Brasil, Rio de Janeiro , (Brazil)
Type
Published Article
Journal
Revista de Saúde Pública
Publisher
Universidade de Sao Paulo Sistema Integrado de Bibliotecas - SIBiUSP
Publication Date
Jul 01, 2020
Volume
54
Identifiers
DOI: 10.11606/s1518-8787.2020054002643
PMID: 32638883
PMCID: PMC7334006
Source
PubMed Central
Keywords
License
Green

Abstract

OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.

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