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A serological survey for antibodies against foot-and-mouth disease virus (FMDV) in domestic pigs during outbreaks in Kenya

Authors
  • Wekesa, Sabenzia N.1, 2
  • Namatovu, Alice3, 4
  • Sangula, Abraham K.1
  • Dhikusooka, Moses T.2, 4
  • Muwanika, Vincent B.2
  • Tjørnehøj, Kirsten5
  • 1 Foot-and-Mouth Disease Laboratory, Embakasi, Nairobi, 00500, Kenya , Nairobi (Kenya)
  • 2 Makerere University, Department of Environmental Management, College of Agricultural and Environmental Sciences, Kampala, Uganda , Kampala (Uganda)
  • 3 Makerere University, Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Kampala, Uganda , Kampala (Uganda)
  • 4 Ministry of Agriculture Animal Industry and Fisheries, National Animal Disease Diagnostics and Epidemiology Centre, Entebbe, Uganda , Entebbe (Uganda)
  • 5 Technical University of Denmark, National Veterinary Institute, Lindholm, Kalvehave, 4771, Denmark , Kalvehave (Denmark)
Type
Published Article
Journal
Tropical Animal Health and Production
Publisher
Springer-Verlag
Publication Date
Jan 18, 2014
Volume
46
Issue
3
Pages
575–581
Identifiers
DOI: 10.1007/s11250-013-0530-0
Source
Springer Nature
Keywords
License
Yellow

Abstract

Foot-and-mouth disease (FMD) is endemic in Kenya and has been well studied in cattle, but not in pigs, yet the role of pigs is recognised in FMD-free areas. This study investigated the presence of antibodies against FMD virus (FMDV) in pigs sampled during a countrywide random survey for FMD in cattle coinciding with SAT 1 FMDV outbreaks in cattle. A total of 191 serum samples were collected from clinically healthy pigs in 17 districts. Forty-two of the 191 sera were from pigs vaccinated against serotypes O/A/SAT 2 FMDV. Antibodies against FMDV non-structural proteins were found in sera from 30 vaccinated and 71 non-vaccinated pigs, altogether 101/191 sera (53 %), and 91 % of these (92/101) also had antibodies measurable by serotype-specific ELISAs, predominantly directed against SAT 1 with titres of 10–320. However, only five high titres against SAT 1 in vaccinated pigs were confirmed by virus neutralisation test (VNT). Due to high degree of agreement between the two ELISAs, it was concluded that positive pigs had been infected with FMDV. Implications of these results for the role of pigs in the epidemiology of FMD in Kenya are discussed, and in-depth studies are recommended.

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