Affordable Access

deepdyve-link
Publisher Website

Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Authors
  • Okba, Nisreen M.A.
  • Widjaja, Ivy
  • Li, Wentao
  • GeurtsvanKessel, Corine H.
  • Farag, Elmoubasher A.B.A.
  • Al-Hajri, Mohammed
  • Park, Wan Beom
  • Oh, Myoung-don
  • Reusken, Chantal B.E.M.
  • Koopmans, Marion P.G.
  • Bosch, Berend-Jan
  • Haagmans, Bart L.
Type
Published Article
Journal
Emerging Infectious Diseases
Publisher
Centers For Disease Control and Prevention
Publication Date
May 01, 2020
Volume
26
Issue
5
Pages
1024–1027
Identifiers
DOI: 10.3201/eid2605.190921
PMID: 32150528
PMCID: PMC7181916
Source
PubMed Central
Keywords
License
Unknown

Abstract

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

Report this publication

Statistics

Seen <100 times