Particulate matter and volatile organic compounds have emerged as a prime environmental concern with increasing air pollution in metropolitan cities leading to lung and heart-related issues. This paper describes a facile and novel method for fabrication of polyester based air filter via surface coating with Sericin for imparting effective removal of particulate matter and volatile organic compounds. A simple dip-coating method followed by thermal fixation has been adopted to coat Sericin on the polyester fiber. The developed changes in surface functionality and morphology of the polyester fiber were confirmed by Attenuated total reflection Fourier-transform infrared spectroscopy and Field emission scanning electron microscopy analysis. The fabricated air filter was tested for removal of particulate matter (generated burning incense stick) and volatile organic compounds (generated vaporizing gasoline), in an indoor chamber. The Sericin coated filter was able to remove the PM2.5 and PM 10 (from 1000 μg/m3 level to 5 μg/m3 in a 6.28 m3 chamber) within 27 and 23 min of operation, respectively. The fabricated filter very effectively removed particulate matter for 2160 cycles with intermittent washing. The Sericin-coated air filter also proved very effective for removal of volatile organic compounds (Benzene, Toluene, Ethylbenzene and Xylene) from an indoor chamber at a varying initial concentration of 100-1000 μg/m3. The adsorption behavior was described by Langmuir-Freundlich (sips) isotherm and pseudo-first order kinetics with minimal error. The maximum adsorption capacity (mg/g) obtained with Sips Isotherm fitting followed the order Xylene (6.97)>Ethyl Benzene (5.68)> Toluene (5.35) >Benzene (4.78). Copyright © 2019 Elsevier Ltd. All rights reserved.