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A Sequential Bioequivalence Design with a Potential Ethical Advantage

Authors
  • Fuglsang, Anders1
  • 1 Fuglsang Pharma, Hiort Lorenzens Vej 6C, Haderslev, 6100, Denmark , Haderslev (Denmark)
Type
Published Article
Journal
The AAPS Journal
Publisher
American Association of Pharmaceutical Scientists
Publication Date
May 29, 2014
Volume
16
Issue
4
Pages
843–846
Identifiers
DOI: 10.1208/s12248-014-9622-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

This paper introduces a two-stage approach for evaluation of bioequivalence, where, in contrast to the designs of Diane Potvin and co-workers, two stages are mandatory regardless of the data obtained at stage 1. The approach is derived from Potvin’s method C. It is shown that under circumstances with relatively high variability and relatively low initial sample size, this method has an advantage over Potvin’s approaches in terms of sample sizes while controlling type I error rates at or below 5% with a minute occasional trade-off in power. Ethically and economically, the method may thus be an attractive alternative to the Potvin designs. It is also shown that when using the method introduced here, average total sample sizes are rather independent of initial sample size. Finally, it is shown that when a futility rule in terms of sample size for stage 2 is incorporated into this method, i.e., when a second stage can be abolished due to sample size considerations, there is often an advantage in terms of power or sample size as compared to the previously published methods.

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