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Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk.

Authors
  • Kidd, La Creis R1
  • Paltoo, Dina N
  • Wang, Songping
  • Chen, Weidong
  • Akereyeni, Folasade
  • Isaacs, William
  • Ahaghotu, Chiledum
  • Kittles, Rick
  • 1 Department of Pharmacology and Toxicology, Cancer Prevention and Control Program, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky.
Type
Published Article
Journal
The Prostate
Publication Date
Aug 01, 2005
Volume
64
Issue
3
Pages
272–282
Identifiers
PMID: 15717311
Source
Medline
License
Unknown

Abstract

The VDR-5132 T/C SNP, resulting in potential elimination of the GATA-1 transcription factor-binding site, may increase prostate cancer susceptibility in African-Americans. Confirmation of these findings is needed in larger observational studies.

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