Affordable Access

deepdyve-link
Publisher Website

Seq’ing identity and function in a repeat-derived noncoding RNA world

Authors
  • O’Neill, Rachel J.1, 2, 3
  • 1 Institute for Systems Genomics, University of Connecticut, Storrs, CT 06269
  • 2 Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269
  • 3 Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06030
Type
Published Article
Journal
Chromosome Research
Publisher
Springer-Verlag
Publication Date
Mar 07, 2020
Volume
28
Issue
1
Pages
111–127
Identifiers
DOI: 10.1007/s10577-020-09628-z
PMID: 32146545
PMCID: PMC7393779
Source
PubMed Central
Keywords
License
Unknown

Abstract

Innovations in high throughout sequencing approaches are being marshaled to both reveal the composition of the abundant and heterogeneous noncoding RNAs that populate cell nuclei and lend insight to the mechanisms by which noncoding RNAs influence chromosome biology and gene expression. This review focuses on some of the recent technological developments that have enabled the isolation of nascent transcripts, chromatin-associated and DNA interacting RNAs. Coupled with emerging genome assembly and analytical approaches, the field is poised to achieve a comprehensive catalog of nuclear noncoding RNAs, including those derived from repetitive regions within eukaryotic genomes. Herein, particular attention is paid to the challenges and advances in the sequence analyses of repeat and transposable element derived noncoding RNAs and in ascribing specific function(s) to such RNAs.

Report this publication

Statistics

Seen <100 times